Quercetin and Sesamin Protect Dopaminergic Cells from MPP+-Induced Neuroinflammation in a Microglial (N9)-Neuronal (PC12) Coculture System
Identifieur interne : 001144 ( Main/Exploration ); précédent : 001143; suivant : 001145Quercetin and Sesamin Protect Dopaminergic Cells from MPP+-Induced Neuroinflammation in a Microglial (N9)-Neuronal (PC12) Coculture System
Auteurs : Julie Bournival [Canada] ; Marilyn Plouffe [Canada] ; Justine Renaud [Canada] ; Cindy Provencher [Canada] ; Maria-Grazia Martinoli [Canada]Source :
- Oxidative Medicine and Cellular Longevity [ 1942-0900 ] ; 2012.
Abstract
A growing body of evidence indicates that the majority of Parkinson's disease (PD) cases are associated with microglia activation with resultant elevation of various inflammatory mediators and neuroinflammation. In this study, we investigated the effects of 2 natural molecules, quercetin and sesamin, on neuroinflammation induced by the Parkinsonian toxin 1-methyl-4-phenylpyridinium (MPP+) in a glial-neuronal system. We first established that quercetin and sesamin defend microglial cells against MPP+-induced increases in the mRNA or protein levels of 3 pro-inflammatory cytokines (interleukin-6, IL-1
Url:
DOI: 10.1155/2012/921941
PubMed: 22919443
PubMed Central: 3418684
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Quercetin and Sesamin Protect Dopaminergic Cells from MPP<sup>+</sup>-Induced Neuroinflammation in a Microglial (N9)-Neuronal (PC12) Coculture System</title><author><name sortKey="Bournival, Julie" sort="Bournival, Julie" uniqKey="Bournival J" first="Julie" last="Bournival">Julie Bournival</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and the Neuroscience Research Group, Université du Québec, Trois-Rivières, Québec, Canada G9A 5H7</nlm:aff><country>Canada</country><wicri:regionArea>Department of Biochemistry and the Neuroscience Research Group, Université du Québec, Trois-Rivières, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Plouffe, Marilyn" sort="Plouffe, Marilyn" uniqKey="Plouffe M" first="Marilyn" last="Plouffe">Marilyn Plouffe</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and the Neuroscience Research Group, Université du Québec, Trois-Rivières, Québec, Canada G9A 5H7</nlm:aff><country>Canada</country><wicri:regionArea>Department of Biochemistry and the Neuroscience Research Group, Université du Québec, Trois-Rivières, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Renaud, Justine" sort="Renaud, Justine" uniqKey="Renaud J" first="Justine" last="Renaud">Justine Renaud</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and the Neuroscience Research Group, Université du Québec, Trois-Rivières, Québec, Canada G9A 5H7</nlm:aff><country>Canada</country><wicri:regionArea>Department of Biochemistry and the Neuroscience Research Group, Université du Québec, Trois-Rivières, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Provencher, Cindy" sort="Provencher, Cindy" uniqKey="Provencher C" first="Cindy" 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wicri:stream="Pmc" wicri:step="Curation">000A61</idno><idno type="wicri:Area/Pmc/Checkpoint">000776</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000776</idno><idno type="wicri:Area/Ncbi/Merge">001228</idno><idno type="wicri:Area/Ncbi/Curation">001228</idno><idno type="wicri:Area/Ncbi/Checkpoint">001228</idno><idno type="wicri:doubleKey">1942-0900:2012:Bournival J:quercetin:and:sesamin</idno><idno type="wicri:Area/Main/Merge">001166</idno><idno type="wicri:Area/Main/Curation">001144</idno><idno type="wicri:Area/Main/Exploration">001144</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Quercetin and Sesamin Protect Dopaminergic Cells from MPP<sup>+</sup>-Induced Neuroinflammation in a Microglial (N9)-Neuronal (PC12) Coculture System</title><author><name sortKey="Bournival, Julie" sort="Bournival, Julie" uniqKey="Bournival J" first="Julie" last="Bournival">Julie Bournival</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and the Neuroscience Research Group, Université du Québec, Trois-Rivières, Québec, Canada G9A 5H7</nlm:aff><country>Canada</country><wicri:regionArea>Department of Biochemistry and the Neuroscience Research Group, Université du Québec, Trois-Rivières, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Plouffe, Marilyn" sort="Plouffe, Marilyn" uniqKey="Plouffe M" first="Marilyn" last="Plouffe">Marilyn Plouffe</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and the Neuroscience Research Group, Université du Québec, Trois-Rivières, Québec, Canada G9A 5H7</nlm:aff><country>Canada</country><wicri:regionArea>Department of Biochemistry and the Neuroscience Research Group, Université du Québec, Trois-Rivières, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Renaud, Justine" sort="Renaud, Justine" uniqKey="Renaud J" first="Justine" last="Renaud">Justine Renaud</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and the Neuroscience Research Group, Université du Québec, Trois-Rivières, Québec, Canada G9A 5H7</nlm:aff><country>Canada</country><wicri:regionArea>Department of Biochemistry and the Neuroscience Research Group, Université du Québec, Trois-Rivières, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Provencher, Cindy" sort="Provencher, Cindy" uniqKey="Provencher C" first="Cindy" last="Provencher">Cindy Provencher</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and the Neuroscience Research Group, Université du Québec, Trois-Rivières, Québec, Canada G9A 5H7</nlm:aff><country>Canada</country><wicri:regionArea>Department of Biochemistry and the Neuroscience Research Group, Université du Québec, Trois-Rivières, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Martinoli, Maria Grazia" sort="Martinoli, Maria Grazia" uniqKey="Martinoli M" first="Maria-Grazia" last="Martinoli">Maria-Grazia Martinoli</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry and the Neuroscience Research Group, Université du Québec, Trois-Rivières, Québec, Canada G9A 5H7</nlm:aff><country>Canada</country><wicri:regionArea>Department of Biochemistry and the Neuroscience Research Group, Université du Québec, Trois-Rivières, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Neuroscience Research Unit, Centre de Recherche du CHUL, Université Laval, Ste-Foy, Québec, Canada G1V 4G2</nlm:aff><country>Canada</country><wicri:regionArea>Neuroscience Research Unit, Centre de Recherche du CHUL, Université Laval, Ste-Foy, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oxidative Medicine and Cellular Longevity</title><idno type="ISSN">1942-0900</idno><idno type="eISSN">1942-0994</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A growing body of evidence indicates that the majority of Parkinson's disease (PD) cases are associated with microglia activation with resultant elevation of various inflammatory mediators and neuroinflammation. In this study, we investigated the effects of 2 natural molecules, quercetin and sesamin, on neuroinflammation induced by the Parkinsonian toxin 1-methyl-4-phenylpyridinium (MPP<sup>+</sup>) in a glial-neuronal system. We first established that quercetin and sesamin defend microglial cells against MPP<sup>+</sup>-induced increases in the mRNA or protein levels of 3 pro-inflammatory cytokines (interleukin-6, IL-1<italic><italic>β</italic></italic> and tumor necrosis factor-alpha), as revealed by real time-quantitative polymerase chain reaction and enzyme-linked immunoabsorbent assay, respectively. Quercetin and sesamin also decrease MPP<sup>+</sup>-induced oxidative stress in microglial cells by reducing inducible nitric oxide synthase protein expression as well as mitochondrial superoxide radicals. We then measured neuronal cell death and apoptosis after MPP<sup>+</sup> activation of microglia, in a microglial (N9)-neuronal (PC12) coculture system. Our results revealed that quercetin and sesamin rescued neuronal PC12 cells from apoptotic death induced by MPP<sup>+</sup> activation of microglial cells. Altogether, our data demonstrate that the phytoestrogen quercetin and the lignan sesamin diminish MPP<sup>+</sup>-evoked microglial activation and suggest that both these molecules may be regarded as potent, natural, anti-inflammatory compounds.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mcgeer, Pl" uniqKey="Mcgeer P">PL McGeer</name></author><author><name sortKey="Mcgeer, Eg" uniqKey="Mcgeer E">EG McGeer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frankola, Ka" uniqKey="Frankola K">KA Frankola</name></author><author><name sortKey="Greig, Nh" uniqKey="Greig N">NH Greig</name></author><author><name sortKey="Luo, W" uniqKey="Luo W">W Luo</name></author><author><name sortKey="Tweedie, D" uniqKey="Tweedie D">D Tweedie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qian, L" uniqKey="Qian L">L Qian</name></author><author><name sortKey="Flood, Pm" 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sortKey="Begley, Dj" uniqKey="Begley D">DJ Begley</name></author><author><name sortKey="Rice Evans, Ca" uniqKey="Rice Evans C">CA Rice-Evans</name></author><author><name sortKey="Abbott, Nj" uniqKey="Abbott N">NJ Abbott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Faria, A" uniqKey="Faria A">A Faria</name></author><author><name sortKey="Pestana, D" uniqKey="Pestana D">D Pestana</name></author><author><name sortKey="Teixeira, D" uniqKey="Teixeira D">D Teixeira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scheepens, A" uniqKey="Scheepens A">A Scheepens</name></author><author><name sortKey="Tan, K" uniqKey="Tan K">K Tan</name></author><author><name sortKey="Paxton, Jw" uniqKey="Paxton J">JW Paxton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vauzour, D" uniqKey="Vauzour D">D Vauzour</name></author><author><name sortKey="Rodriguez Mateos, A" uniqKey="Rodriguez Mateos A">A Rodriguez-Mateos</name></author><author><name sortKey="Corona, G" uniqKey="Corona G">G Corona</name></author><author><name sortKey="Oruna Concha, Mj" uniqKey="Oruna Concha M">MJ Oruna-Concha</name></author><author><name sortKey="Spencer, Jpe" uniqKey="Spencer J">JPE Spencer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, Mm" uniqKey="Khan M">MM Khan</name></author><author><name sortKey="Ishrat, T" uniqKey="Ishrat T">T Ishrat</name></author><author><name sortKey="Ahmad, A" uniqKey="Ahmad A">A Ahmad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsieh, Pf" uniqKey="Hsieh P">PF Hsieh</name></author><author><name sortKey="Hou, Cw" uniqKey="Hou C">CW Hou</name></author><author><name sortKey="Yao, Pw" uniqKey="Yao P">PW Yao</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Bournival, Julie" sort="Bournival, Julie" uniqKey="Bournival J" first="Julie" last="Bournival">Julie Bournival</name></noRegion><name sortKey="Martinoli, Maria Grazia" sort="Martinoli, Maria Grazia" uniqKey="Martinoli M" first="Maria-Grazia" last="Martinoli">Maria-Grazia Martinoli</name><name sortKey="Martinoli, Maria Grazia" sort="Martinoli, Maria Grazia" uniqKey="Martinoli M" first="Maria-Grazia" last="Martinoli">Maria-Grazia Martinoli</name><name sortKey="Plouffe, Marilyn" sort="Plouffe, Marilyn" uniqKey="Plouffe M" first="Marilyn" last="Plouffe">Marilyn Plouffe</name><name sortKey="Provencher, Cindy" sort="Provencher, Cindy" uniqKey="Provencher C" first="Cindy" last="Provencher">Cindy Provencher</name><name sortKey="Renaud, Justine" sort="Renaud, Justine" uniqKey="Renaud J" first="Justine" last="Renaud">Justine Renaud</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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